Process Engineering Scientific Associate II – Stem Cell Culture/Bioreactors

Vertex Pharmaceuticals Inc (US) Cambridge, MA

About the Job

In June 2019, Vertex announced the establishment of a new research site in the Boston area where research, development, and clinical manufacturing for cell and genetic therapies will be primarily based. Cell and genetic therapies represent two rapidly emerging therapeutic modalities with the potential to treat—and even cure—several of the diseases Vertex is focused on, including sickle cell disease, Duchenne muscular dystrophy and type 1 diabetes. Further investment in a research site specifically designed to advance these programs will be key to Vertex’s continued and sustained leadership in these exciting approaches. At Vertex Cell and Genetic Therapies (VCGT) our research teams will bring together the best biology, technologies and enhanced manufacturing capabilities to ensure we bring these cutting-edge transformative therapies to patients as quickly as possible.

Key Responsibilities:

  • Support and execute experiments for robust and scaled platform for pluripotent stem cell expansion/directed differentiation. Includes assembling raw materials, following specific standard operating procedures (SOP), aseptic technique, completing batch records, and reporting deviations
  • Perform cell culture maintenance and aliquoting preparation
  • Participate in technology transfer to manufacturing and provide training for GMP production
  • Maintain electronic laboratory notebooks, analyze and present experimental data to the team, and write study reports
  • Ensure raw materials are identified and available in time for Process Development activities
  • Support Operations group to ensure proper coordination of resources

Other duties:

  • Perform data review of technical reports
  • Draft Standard Operating Procedures (SOPs) and batch records for manufacturing in collaboration with Research and Quality Systems groups
  • Ensure raw materials are identified and available in time for laboratory activities
  • Communicate with Operations group to coordinate the maintenance of laboratory equipment

Required:

  • Bachelor’s degree Minimum 1 - 2 years of industrial experience in a process related science with some cell culture experience

Preferred:

  • Prior experience with cell culture bioreactors
  • Experience with embryonic or induced pluripotent stem cell culture
  • Familiarity with flow cytometry, bioassays, and cell counting methods