Scientist (Blood cell development and disorders)
About the Job
At St. Jude Children’s Research Hospital, talented faculty and staff work together and with colleagues worldwide-to advance the research and treatment of pediatric cancer and other catastrophic diseases.
In anticipation of future growth, we are seeking outstanding, highly motivated, and creative candidates for multiples roles in a new genome editing group. This group is part of a multidisciplinary team of scientists and clinical researchers to develop optimized cures for sickle cell disease by combining innovative stem cell transplantation approaches with emerging genome editing technologies. Our ongoing therapeutic pipeline is fueled by internal scientific discoveries directed from “bench-to-bedside” and academic collaborations.
You will have the opportunity to learn about and support new exciting projects such as:
- Development and optimization of pre-clinical genome editing strategies for sickle adult hemoglobin.
- Process development and IND-enabling studies (Pharm/Tox)
Apply today! A cover letter is highly recommended.
- Perform studies to improve genome editing in CD34+ HSCs.
- Perform IND-enabling experiments
- Evaluate scale-up and close-system processes to ensure reproducibility of drug product.
- Establish tracking and trending analyses of process development and pilot runs.
- Exploratory research on novel genome editing and delivery tools.
- Draft documentation (protocols, batch records, reports) to standardize and transfer process to GMP facility
- PhD in Life Sciences, Bioengineering, or related discipline or BS/MS with 2-5 years of relevant experience.
- Experience in cell-based therapy culture and process
- Experience in HSC CD34+ cell isolation, culture, and freezing.
- Experience with genome editing tools (Nucleases/base editing)
- Experience with basic molecular biology techniques
- Ability to communicate effectively with strong communications skills and a collegial personality.
- Ability to operate in a fast-paced, multi-disciplinary environment.
- Must be an independent thinker, meticulous, detail-oriented, and analytical.
- Must be highly motivated, have excellent organizational, communication and interpersonal skills.
- Must be able to work independently and as part of a multi-disciplinary team.
- cGMP experience in the cell and gene therapy spaces.
- Corporate experience within biotech/pharmaceutical company or a CRO/CMO.
- Experience in biologics manufacturing.
- Knowledge of process development concepts for biological manufacturing; basic principles of various engineering disciplines.
- Experience in NGS sequencing and data analysis
- Experience in automated cell processing systems such as Sepax, CliniMACS Prodigy & Plus, bioreactors, or other cell therapy processing instruments.
- Familiarity with flow cytometry; analysis and sorting
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