About the Job
St. Jude Children's Research Hospital is consistently ranked on Fortune Magazine's "100 Best Places to Work For" list. Because at our world-class pediatric research hospital, every one of our professionals shares our commitment to make a difference in the lives of the children we serve.
This is an exciting opportunity for a self-motivated person to join Dr. Krenciute’s laboratory in the Department of Bone Marrow Transplantation and Cellular Therapy at St. Jude. The research focus is to develop an effective immunotherapy for brain tumors using genetically modified T cells. Our goal is to generate and optimize CAR-T cells to target pediatric brain tumor associated antigens and to understand tumor escape mechanism in order to design superior immunotherapy treatments. This research employs different genetic manipulations of CAR T-cell effector functions to reduce resistance to tumor microenvironment.
The Researcher will have the responsibility of culturing T cells and tumor cells, genetically engineering T cells with chimeric antigen receptors (CARs), silencing genes in CAR T cells using CRISPR-Cas9 technology, running flow cytometry analysis on tumor cells and T cells, running ELISAs, designing and cloning transgenes, analyzing data and presenting results at the lab meetings.
In addition to be responsible of coordinating efficient laboratory operations, keep accurate data records and notebooks, organize lab records, maintain inventories and performs other duties as assigned or directed in order to meet the goals and objectives of the lab.
- Bachelor's degree in relevant scientific area is required. Will also consider current students with an anticipated graduation date within 3 months of application. Verification of degree is required prior to start date.