Postdoctoral Research Associate
About the Job
Postdoctoral Positions Available
Positions are available in the Department of Hematology at St. Jude Children’s Research Hospital (Memphis, Tennessee, USA) to study the fundamental biology of hematopoietic stem cells (HSCs).
HSCs represent the most therapeutically exploited adult stem cell compartment, used routinely to treat leukemia and hematologic disease via HSC transplantation. Our major goals are to 1) illuminate the intrinsic and extrinsic factors that control the ability of HSC to home to, engraft, and repopulate the hematopoietic compartment after transplantation, 2) better understand the specification of HSCs and the hematopoietic hierarchy during ontogeny and 3) uncover how chronic hematologic disease corrupts HSCs, with a particular focus on sickle cell disease.
We hope to leverage this knowledge to design therapies targeted at improving HSC transplantation for hematologic disease and gene therapy, as well as illuminate mechanisms of hematopoietic failure during chronic hematologic disease.
Current ongoing projects include discovering novel molecular regulators of HSC transplantation, exploring novel checkpoints regulating the developing HSC pool during ontogeny and interrogating HSC function during Sickle Cell Disease in children and adults. We employ both genetic mammalian model systems and primary patient samples to pursue these aims. We are also heavily invested in single cell gene expression and architecture approaches to explore these questions.
St. Jude Children’s Research Hospital, located in Memphis, Tennessee, USA, is a premier center for research and treatment of potentially fatal childhood diseases, including cancer and certain blood, genetic, and immunodeficiency disorders. The hospital’s mission is to advance cures, and means of prevention, for pediatric catastrophic diseases through research and treatment. St. Jude is dedicated to providing unsurpassed patient care and to advancing the health of children through biomedical research.
If interested, please contact Shannon McKinney-Freeman at Shannon.firstname.lastname@example.org
The successful candidate will employ mouse genetics, ex vivo cell culture, flow cytometry, molecular biology and xenografts to study both mouse and human HSCs. This position is ideal for someone with a Ph.D and/or M.D. seeking to develop expertise in stem cell biology in an intimate and vibrant laboratory setting. Computational expertise or experience exploring large single cell datasets would be a particular strength for this position.