Lead-Bioinformatics Research Scientist

St Jude Distribution
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Job Details

  • Location: Memphis, TN, 38105
  • Date Posted: 2023-02-25
  • Employment Type: Full Time
  • Category: Biotechnology/Pharmaceutical
  • Req Number: 50266
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At St. Jude Children’s Research Hospital, we know what can be achieved when the brightest scientific minds face the fewest barriers. As a bioinformatics research scientist in Dr. Douglas Green's lab within the Department of Immunology, you will have numerous opportunities to be involved in cutting-edge immunological researcand publish in high-impact journals. You will collaborate on projects related to T cell receptor repertoires, mechanisms of autoantibody generation, the regulation of inflammatory pathways, and the epigenetic and molecular regulation of immune cell differentiation. You will maintain standard analytical pipelines, and conduct analyses on research data produced from a variety of biotechnology platforms, potentially including microarrays, RNA sequencing, single-cell transcriptomics, next-generation sequencing systems, spatial transcriptomic, and scientific imaging systems. This work will entail the evaluation, deployment, and utilization of new software tools to meet the growing needs of the department.

This position is also responsible for the preparation, maintenance, and mining of institutional databases. This would include the evaluation of user needs for data storage, analysis, and retrieval, the development of new databases, as well as interfacing to existing databases. Experience in a basic scripting language (Python, Perl, R) under Linux/Unix environment is required. Experience with a general-purpose programming language (C/C++, JavaScript) preferred. Experience with PHP would be useful. Background in molecular biology, cell biology, immunology, and/or cancer biology, wet lab environment, and familiarity with next-generation sequence analysis or imaging analysis is preferred. 

Publication links

LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer’s Disease

LC3-Associated Phagocytosis in Myeloid Cells Promotes Tumor Immune Tolerance

ESCRT-III Acts Downstream of MLKL to Regulate Necroptotic Cell Death and Its Consequences

BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation

Metabolic maintenance of cell asymmetry following division in activated T lymphocytes

Apoptosis-Inducing-Factor-Dependent Mitochondrial Function Is Required for T Cell but Not B Cell Function

Sublethal cytochrome c release generates drug-tolerant persister cells.

cBAF complex components and MYC cooperate early in CD8+ T cell fate.


Salary is highly competitive (comparable to the industry) and employee benefits are outstanding. Relocation assistance is available. Working at St. Jude provides the opportunity to make a tangible difference in pediatric cancer patient care and survival and St. Jude has been consistently ranked in Fortune magazine’s “100 Best Places to Work” list and is exceptionally positively reviewed on GlassDoor.


  • Leads the analysis and interpretation of data for assigned projects under the direction of the Director.
  • Contribute ideas to automate and improve existing analysis methods.
  • Leads the development and establishment of standard analytical workflows for assigned projects.
  • Assists with establishing and documenting protocols or best practices for common research tasks.
  • Learns new bioinformatics techniques to address challenging data questions and meet the needs of  investigators.
  • Contributes to the preparation and submission of manuscripts for publication as needed.
  • Presents to collaborators and team members to report scientific discoveries and educate researchers about relevant methods, software or scientific results.
  • Performs other duties as assigned to meet the goals and objectives of the department and institution.
  • Maintains regular and predictable attendance.

Minimum Education

  • Bachelor's degree in bioinformatics, cheminformatics, statistics/computer science (with a background in biological sciences or chemistry) or related field.
  • Master's degree or PhD preferred.

Minimum Experience

  • Minimum Requirement: Bachelor's degree with 10+ years of relevant post-degree work in bioinformatics, cheminformatics, statistics/computer science (with a background in biological sciences or chemistry).
  • Experience Exception: Master's degree with 8+ years of relevant post-degree experience (OR) PhD with 5+ years of relevant post-degree experience.
  • Substantial experience in at least one programming or scripting language and at least one statistical package, with R preferred.

Required Credentials


Other Information

St. Jude is an Equal Opportunity Employer

No Search Firms:

St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.

COVID-19 vaccine:

St. Jude Children’s Research Hospital has mandated the COVID-19 vaccine for all employees, excluding those with an approved medical or religious accommodation, as a condition of employment.