At St. Jude Children’s Research Hospital, we know what can be achieved when the brightest scientific minds face the fewest barriers. As a bioinformatics research scientist in Dr. Douglas Green's lab within the Department of Immunology, you will have numerous opportunities to be involved in cutting-edge immunological research and publish in high-impact journals. You will collaborate on projects related to T cell receptor repertoires, mechanisms of autoantibody generation, the regulation of inflammatory pathways, and the epigenetic and molecular regulation of immune cell differentiation. You will maintain standard analytical pipelines, and conduct analyses on research data produced from a variety of biotechnology platforms, potentially including microarrays, RNA sequencing, single-cell transcriptomics, next-generation sequencing systems, spatial transcriptomic, and scientific imaging systems. This work will entail the evaluation, deployment, and utilization of new software tools to meet the growing needs of the department.
LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer’s Disease
LC3-Associated Phagocytosis in Myeloid Cells Promotes Tumor Immune Tolerance
ESCRT-III Acts Downstream of MLKL to Regulate Necroptotic Cell Death and Its Consequences
BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation
Metabolic maintenance of cell asymmetry following division in activated T lymphocytes
Apoptosis-Inducing-Factor-Dependent Mitochondrial Function Is Required for T Cell but Not B Cell Function
Sublethal cytochrome c release generates drug-tolerant persister cells.
cBAF complex components and MYC cooperate early in CD8+ T cell fate.
Salary is highly competitive (comparable to the industry) and employee benefits are outstanding. Relocation assistance is available. Working at St. Jude provides the opportunity to make a tangible difference in pediatric cancer patient care and survival and St. Jude has been consistently ranked in Fortune magazine’s “100 Best Places to Work” list and is exceptionally positively reviewed on GlassDoor.
- Leads the analysis and interpretation of data for assigned projects under the direction of the Director.
- Contribute ideas to automate and improve existing analysis methods.
- Leads the development and establishment of standard analytical workflows for assigned projects.
- Assists with establishing and documenting protocols or best practices for common research tasks.
- Learns new bioinformatics techniques to address challenging data questions and meet the needs of investigators.
- Contributes to the preparation and submission of manuscripts for publication as needed.
- Presents to collaborators and team members to report scientific discoveries and educate researchers about relevant methods, software or scientific results.
- Performs other duties as assigned to meet the goals and objectives of the department and institution.
- Maintains regular and predictable attendance.
- Bachelor's degree in bioinformatics, cheminformatics, statistics/computer science (with a background in biological sciences or chemistry) or related field.
- Master's degree or PhD preferred.
- Minimum Requirement: Bachelor's degree with 10+ years of relevant post-degree work in bioinformatics, cheminformatics, statistics/computer science (with a background in biological sciences or chemistry).
- Experience Exception: Master's degree with 8+ years of relevant post-degree experience (OR) PhD with 5+ years of relevant post-degree experience.
- Substantial experience in at least one programming or scripting language and at least one statistical package, with R preferred.