CRISPR-Cas Genome Editing Research Lab Specialist

St. Jude Children's Research Hospital Columbus, OH

About the Job

The laboratory of Shengdar Q. Tsai is seeking outstanding, highly motivated, and creative candidates for a Research Lab Specialist to help advance genome editing strategies to treat sickle cell disease to a Phase 1 clinical trial. This exciting opportunity is in our  pharmacology/toxicology group, working on defining the mechanism of action and potential safety of our lead therapeutic approach.


You will have the opportunity to work with a talented interdisciplinary team of scientists to develop a cellular therapy with the goal of treating patients here at St. Jude Children’s research hospital and worldwide. The ideal candidate will have a combination of experience with genome editing and human hematopoietic stem cells.


In this position, you will gain extensive experience and training in genome editing, sickle cell disease, high-throughput genomics, and human hematopoietic stem cells.


Please include a cover letter describing the rationale for your interest in this position to be competitive.

  • Design and execute IND-enabling experiments to characterize the pharmacology and toxicology of a genome edited human hematopoietic stem cell product to treat sickle cell disease.
  • Interact with scientists within the Tsai lab as well as process development and GMP groups to advance this therapeutic approach.
  • Define the safety or genome-wide activities of therapeutic genome editors.
  • Characterize the efficacy and potency of the cellular drug product in in vitro and xenotransplantation assays.
  • Carefully organize and document experiments in electronic laboratory notebook.


  • Bachelor's degree in appropriate scientific field is required.

  • A minimum of eight (8) years of relevant post-degree work experience, with at least five (5) years at the Sr. Research Tech level, is required with a Bachelor's degree
  • A minimum of seven (7) years of relevant post-degree work experience, with at least (5) years at the Sr. Research Tech level, is required with a Master's degree
  • A minimum of four (4) years of relevant work experience including post-doctoral and/or technical staff experience is required with a Ph.D


Successful applicants will have excellent communication skills, and a B.S. or equivalent degree in molecular biology, cell biology, genetics, genomics, hematology, or a related area.

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