CRISPR-Cas Genome Editing Research Lab Specialist
About the Job
The laboratory of Shengdar Q. Tsai is seeking outstanding, highly motivated, and creative candidates for a Research Lab Specialist to help advance genome editing strategies to treat sickle cell disease to a Phase 1 clinical trial. This exciting opportunity is in our pharmacology/toxicology group, working on defining the mechanism of action and potential safety of our lead therapeutic approach.
You will have the opportunity to work with a talented interdisciplinary team of scientists to develop a cellular therapy with the goal of treating patients here at St. Jude Children’s research hospital and worldwide. The ideal candidate will have a combination of experience with genome editing and human hematopoietic stem cells.
In this position, you will gain extensive experience and training in genome editing, sickle cell disease, high-throughput genomics, and human hematopoietic stem cells.
Please include a cover letter describing the rationale for your interest in this position to be competitive.
- Design and execute IND-enabling experiments to characterize the pharmacology and toxicology of a genome edited human hematopoietic stem cell product to treat sickle cell disease.
- Interact with scientists within the Tsai lab as well as process development and GMP groups to advance this therapeutic approach.
- Define the safety or genome-wide activities of therapeutic genome editors.
- Characterize the efficacy and potency of the cellular drug product in in vitro and xenotransplantation assays.
- Carefully organize and document experiments in electronic laboratory notebook.
- Bachelor's degree in appropriate scientific field is required.
- A minimum of eight (8) years of relevant post-degree work experience, with at least five (5) years at the Sr. Research Tech level, is required with a Bachelor's degree
- A minimum of seven (7) years of relevant post-degree work experience, with at least (5) years at the Sr. Research Tech level, is required with a Master's degree
- A minimum of four (4) years of relevant work experience including post-doctoral and/or technical staff experience is required with a Ph.D
Successful applicants will have excellent communication skills, and a B.S. or equivalent degree in molecular biology, cell biology, genetics, genomics, hematology, or a related area.