Biotech Scientist (Blood cell development and disorders)
About the Job
At St. Jude Children’s Research Hospital, talented faculty and staff work together and with colleagues worldwide-to advance the research and treatment of pediatric cancer and other catastrophic diseases.
In anticipation of future growth, we are seeking outstanding, highly motivated, and creative candidates for scientist roles in a new clinical genome editing group that is part of a multidisciplinary team of scientists and clinical researchers to help advance genome editing strategies to treat sickle cell disease to a Phase 1 clinical trial. Our ongoing therapeutic pipeline is fueled by internal scientific discoveries directed from “bench-to-bedside” and academic collaborations.
You will have the opportunity to work with a talented interdisciplinary team of scientists to develop a cellular therapy with the goal of treating patients here at St. Jude Children’s Research Hospital and worldwide. The ideal candidate will have a combination of experience with genome editing and human hematopoietic stem cells.
You will have the opportunity to learn about and support new exciting projects such as:
- Development and optimization of pre-clinical genome editing strategies for sickle adult hemoglobin.
- Process development and IND-enabling studies (Pharm/Tox)
Apply today! A cover letter is highly recommended.
- Perform studies to improve genome editing and culture of human hematopoietic stem cells.
- Design and execute IND-enabling experiments to characterize the pharmacology of a genome edited human hematopoietic stem cell product to treat sickle cell disease.
- Characterize the efficacy and potency of the cellular drug product in in vitro and xenotransplantation assays.
- Interact and collaborate with multidisciplinary team to advance the program.
- Evaluate scale-up and close-system processes to ensure reproducibility of drug product.
- Establish tracking and trending analyses of process development and pilot runs.
- Draft documentation (protocols, batch records, reports) to standardize and transfer process to GMP facility.
- PhD in Life Sciences, Bioengineering, or related discipline.
- Strong experience and knowledge in hematology and hematopoietic stem cell biology.
- Experience in cell-based therapy culture and process.
- Experience with genome editing tools (Nucleases/base editing)
- Ability to communicate effectively with strong communications skills and a collegial personality.
- Ability to operate in a fast-paced, multi-disciplinary environment.
- Must be an independent thinker, meticulous, detail-oriented, and analytical.
- Must be highly motivated, have excellent organizational, communication and interpersonal skills.
- Must be able to work independently and as part of a multi-disciplinary team.
- cGMP experience in the cell and gene therapy spaces.
- Experience within biotech/pharmaceutical company or a CRO/CMO.
- Experience in biologics manufacturing.
- Knowledge of process development concepts for biological manufacturing; basic principles of various engineering disciplines.
- Experience in NGS sequencing and data analysis.
- Experience in automated cell processing systems such as Sepax, CliniMACS Prodigy & Plus, bioreactors, or other cell therapy processing instruments.
- Familiarity with flow cytometry; analysis and sorting.
- Animal experience, familiar with humanized mouse xenotransplantation models (NSG/NBSGW)
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