Bioinformatics Scientist

Thermo Fisher Scientific Ann Arbor, MI

About the Job

Scientist III, Bioinformatics
Requisition ID: 126235BR

Thermo Fisher Scientific Inc. is the world leader in serving science, with annual revenue exceeding $25 billion. Our Mission is to enable our customers to make the world healthier, cleaner and safer. Whether our customers are accelerating life sciences research, solving complex analytical challenges, improving patient diagnostics and therapies or increasing productivity in their laboratories, we are here to support them.

US - Ann Arbor, MI
Clinical Next-Generation Sequencing Division
The position is based in Ann Arbor, MI and is part of the extended Bioinformatics team within the Clinical Next Generation Sequencing Division. The mission of this business unit is to develop next-generation sequencing based solutions to support research applications in oncology and other important unmet medical needs.

How will you make an impact?
You will join a team of talented engineers and scientists, passionate about bringing actionable insights to precision oncology. The successful candidate will work collaboratively in a matrix environment to develop data analysis strategies to address key questions about cancer for our internal and external customers. Applications include diagnostics, target and biomarker discovery, indication selection, and clinical development strategies.

Next-Generation Sequencing (NGS) is rapidly reshaping life sciences, translational research, and clinical diagnostics. At Thermo Fisher Scientific, a leading contributor in these fields, we are dedicated to improving the quality of sequencing and broadening the range of its applications.

We are seeking individuals with expertise in bioinformatics and an understanding of the cancer genome to identify relevant cancer driver aberrations. If you are a motivated and innovative bioinformatics scientist seeking to advance your career in these fields, we would like to invite you to join our NGS R&D Bioinformatics team in Ann Arbor MI.

What will you do?

  • Your primary responsibility is supporting new product introductions (NPI), focusing on sequencing and analysis strategies for oncology as well as other novel applications.
  • Additional responsibilities include providing support for on-market products and using innovative approaches for system improvement and troubleshooting.
  • Balance between providing customized data analysis to support bench scientists and improving core sequencing technologies.
  • Perform analyses such as variant discovery, variant calling, CNV detection, and fusion calling. Interpret analyses, summarize results, and share findings with appropriate teams.
  • Work closely with program management, product management, molecular biology, software, instrument, and other bioinformatics teams.
  • Understand and follow the product development process guidelines around design, development, and testing.
  • Play a pivotal role in algorithm and tool development, translating new product requirements into prototype and production-level software, testing and integrating your code, and coordinating improvements.
You will remain up to date with the latest developments in high-throughput genomics and oncology informatics. You may engage with collaborators or users, and you may attend and present at scientific meetings as appropriate.

How will you get here?
Education
MS degree with 3+ years of experience or PhD in bioinformatics, computational biology, statistics, computer science, or biological sciences, preferably with application experience in a related area such as oncology, reproductive health, inherited disease or human genetics.

Experience
  • Hands-on experience with public cancer genomic data sources such as TCGA, COSMIC, and ClinVar is required.
  • Experience with PCR primer design, sequence and motif analysis, and cancer genomics is particularly welcome.
  • Proven track record of scientific publications and scientific conference presentations is a strong plus.
  • Familiarity with product development and/or project management will make you a stronger candidate, along with knowledge of office productivity software such as Microsoft Office and Atlassian.
Knowledge, Skills, Abilities
  • Solid knowledge of next-generation sequencing analysis under the Linux environment, with good understanding of software engineering and data analysis principles.
  • Proficiencies in a scripting language (Python preferred or Perl), a statistical package (R preferred or MATLAB), and shell-scripting are required.
  • Computational pipeline development and database management, as well as solid background in genomics and statistics.
  • Effective communication skills, especially for presenting scientific results, working collaboratively in a team, and documenting work.
  • Ability to work in a multi-disciplinary and geographically distributed team environment.
  • Ability to handle ambiguity and rapid change.
  • Strong drive for problem-solving and continuous improvement, with the willingness and courage to work through obstacles.

Our global team of more than 75,000 colleagues delivers an unrivaled combination of innovative technologies, purchasing convenience and pharmaceutical services through our industry-leading brands, including Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, Unity Lab Services and Patheon. For more information, please visit www.thermofisher.com